What are the HIV postexposure prophylaxis (PEP) regimens for patients older than 13 years with normal renal function?

Updated: Jul 08, 2021
  • Author: Derek T Larson, DO; Chief Editor: Michael Stuart Bronze, MD  more...
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Patients older than 13 years with normal renal function (CrCl ≥60 mL/min), including pregnant individuals

The preferred 3-drug regimen is as follows:


Caution: Coadministration of raltegravir or dolutegravir with antacids or cations (iron, calcium, or magnesium) can reduce drug absorption and therefore efficacy of PEP.

An alternative regimen is as follows:

  • Tenofovir disoproxil fumarate 300 mg/emtricitabine 200 mg (Truvada) daily  AND
  • Darunavir 800 mg daily  AND
  • Ritonavir 100 mg daily OR  cobicistat 150 mg daily (as pharmacokinetic booster)

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