Which medications are administered to prevent STIs following a sexual assault?

Updated: Jul 08, 2021
  • Author: Derek T Larson, DO; Chief Editor: Michael Stuart Bronze, MD  more...
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Gonorrhea, as follows:

  • Ceftriaxone 500 mg IM (or 1 gram for patients over 300lbs), once  PLUS
  • Doxycycline 100 mg orally, twice daily, for 7 days (prefered)  OR
  • Azithromycin 1 gram orally, once (alternative in pregnancy or if adherence to doxycycline regimen is uncertain) 

Chlamydia, as follows:

Trichomoniasis (females only), as follows:

Human papillomavirus (HPV) infection, as follows:

  • In males aged 9-21 years and females aged 9-26 years, initiate  HPV vaccine series (upon presentation and at 1-2 months and 4-6 months)
  • For those 45 years or younger, the FDA has approved use of HPV vaccination, although the CDC guidelines have not yet included this. [31]

Treatment to be administered after bodily fluid exposures (including, but not limited to, sexual encounters) is discussed below.

Hepatitis B, as follows:

  • If patient immunized and documented vaccine responder: No action
  • If patient immunized without documented vaccine response: Booster hepatitis B vaccine dose once
  • If patient non-immunized:  Hepatitis B vaccine series (upon presentation and then at 1-2 months and 4-6 months) and  hepatitis B immune globulin given once

Hepatitis C: PEP not currently recommended

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