What are the guidelines on HIV prophylaxis following sexual assault?

Updated: Jul 08, 2021
  • Author: Derek T Larson, DO; Chief Editor: Michael Stuart Bronze, MD  more...
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Guidelines for use of HIV postexposure prophylaxis (PEP) regimens in at-risk patients from either occupational (oPEP) or non-occupational (nPEP) exoisyres have been issued by the Centers for Disease Control and Prevention (CDC), [1]  the Unites States Public Health Service, [2] and The World Health Organization. [3]  Guidelines pertaining to non-occupational exposures (including but not limited to sexual assault, high-risk consensual sexual encounters, and injection drug use) are reviewed and summarized below. For information regarding occupational exposures, see HIV Postexposure Prophylaxis, Occupational.

Updates to this article are as follows:

  • Adoption of CDC interim guidance for increased doses of ceftriaxone for the treatment of gonorrhea [4]
  • Addition of dolutegravir and boosted darunavir into treatment algorithm
  • Integration of data regarding treatment as prevention (U=U) 
  • Update of use of integrase-inhibitors in individuals of childbearing potential

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