What are the possible adverse effects of trimethoprim/sulfamethoxazole (TMP-SMZ) for the treatment of cat scratch disease (CSD)?

Updated: Feb 16, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Michael Stuart Bronze, MD  more...
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TMP-SMZ doses can include 8-12 mg/kg/d orally of TMP and 40-60 mg/kg/d orally of SMX every 12 hours. TMP-SMZ can cause rashes and, occasionally, Stevens-Johnson syndrome. Anemia and neutropenia may occur, and a mild decrease in platelet count is common.

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