What is the role of immunoglobulins testing in the diagnosis of cat scratch disease (CSD)?

Updated: Feb 16, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

A standard pattern of anti-B henselae IgG and IgM production does not seem to exist. Some patients with CSD have high levels of both IgG and IgM, some have high levels of only IgM, and others have low levels of both. The timing of IgG and IgM response is variable, and cross-reactivity between different Bartonella species may occur. In one study, 25% of patients remained IgG seropositive for longer than 1 year. Antibody kinetics do not reliably predict severity or duration of disease.


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