How was the diagnosis of cat scratch disease (CSD) confirmed?

Updated: Feb 16, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Michael Stuart Bronze, MD  more...
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Margileth et al studied a series of 1312 patients referred for chronic lymphadenopathy. The diagnosis of CSD was confirmed in 1174 patients via catscratch antigen (CSA) testing, similar to the tuberculosis purified protein derivative (PPD) test. Of this cohort, 88% exhibited a typical course characterized by lymphadenopathy lasting an average of 3 months. Fever and malaise/fatigue were described in approximately one third of patients, none of whom was symptomatic for longer than 1 month.

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