What is the pathophysiology of cat scratch disease (CSD)?

Updated: Feb 16, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

The hallmark of CSD is regional adenopathy proximal to the site of inoculation. In immunocompetent patients, Bartonella infection causes a granulomatous and suppurative response. In immunocompromised patients, the response to Bartonella infection can be vasculoproliferative with neovascularization. Bartonella is able to promote angioproliferation through adhesin A, which is observed in bacillary angiomatosis, peliosis, and verruga peruana.


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