Which medications in the drug class Antineoplastics, Other are used in the treatment of Cutaneous T-Cell Lymphoma?

Updated: Aug 15, 2018
  • Author: Lauren C Pinter-Brown, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Antineoplastics, Other

These agents inhibit cell growth and proliferation.

Chlorambucil (Leukeran)

Chlorambucil alkylates and cross-links strands of DNA, inhibiting DNA replication and RNA transcription.

Vorinostat (Zolinza)

Vorinostat is a histone deacetylase (HDAC) inhibitor. HDAC inhibition causes hypoacetylation of core nucleosomal histones, condenses chromatin structure, and represses gene transcription. This agent is indicated for treatment of progressive, persistent, or recurrent cutaneous T-cell lymphoma.

Methotrexate (Trexall, Otrexup, Rasuvo)

Methotrexate is a folic acid antagonist that inhibits dihydrofolate reductase, an enzyme needed to make DNA.

Etoposide (Toposar)

Etoposide inhibits topoisomerase II and causes DNA strand breakage, resulting in the arrest of cell proliferation in the late S or early G2 portion of the cell cycle.

Romidepsin (Istodax)

Romidepsin is a histamine deacetylase (HDAC) inhibitor. It is indicated for cutaneous T-cell lymphoma in patients who have received at least one prior systemic therapy.

Denileukin diftitox (Ontak)

This product was discontinued in January 2014. This is a fusion protein (amino acid sequence of diphtheria linked to IL-2 amino acid sequence) that selectively delivers cytotoxic activity of diphtheria toxin to targeted cells. Denileukin diftitox is used only in T-cell lymphoma in which malignant cells express the CD25 component of the IL-2 receptor. It interacts with the high-affinity IL-2 receptor on the surface of malignant cells to inhibit intracellular protein synthesis, which in turn causes cell death.

Carmustine (BiCNU)

Carmustine alkylates and cross-links DNA strands, inhibiting cell proliferation.

Mechlorethamine (Mustargen)

This is a topical nitrogen mustard that, as an alkylating agent, inhibits DNA replication.

Bexarotene (Targretin)

Bexarotene (Targretin) is an X-receptor–specific retinoid. The receptor works as transcription factors that regulate genes that control cellular differentiation and proliferation. It may inhibit sebaceous gland differentiation and abnormal keratinization.


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