Which studies are recommended to establish a diagnosis of mycosis fungoides/Sezary syndrome (MF/SS) in cutaneous T-cell lymphoma (CTCL)?

Updated: Aug 15, 2018
  • Author: Lauren C Pinter-Brown, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

The NCCN considers the following studies essential for establishing a diagnosis of MF/SS [123] :

  • Biopsy of suspicious skin sites (multiple biopsies may be necessary to capture the pathologic variability of disease at diagnosis)

  • Dermatopathology review of slides (including evaluation for presence of transformation or areas of folliculotropism

  • Immunohistochemistry panel of skin biopsy (CD2, CD3, CD4, CD5, CD7, CD8, CD20, CD30, CD25, CD56, TIA1, granzyme B, ßF1, TCR-CγM1)

  • Molecular analysis to detect clonal T-cell antigen receptor (TCR) gene rearrangements or other assessment of clonality


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