How is follicular mycosis fungoides cutaneous T-cell lymphoma (CTCL) treated?

Updated: Aug 15, 2018
  • Author: Lauren C Pinter-Brown, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Perifollicular localization of the dermal infiltrates in folliculotropic mycosis fungoides is often less responsive to skin-targeted therapies (eg, PUVA, topical nitrogen mustard) than is classic plaque-stage mycosis fungoides; total skin electron beam irradiation is superior. [117] However, because sustained complete remissions are rarely achieved with electron beam therapy, PUVA combined with retinoids or interferon alfa should be considered, although persistent tumors can be effectively treated with local radiotherapy.

Follicular mycosis fungoides may benefit from isotretinoin for persistent cysts and comedones. [118] Many patients benefit from PUVA therapy, although they may not respond as well as patients with classic mycosis fungoides do. [63] Early syringotropic cutaneous T-cell lymphoma may be treated with local radiotherapy, with excellent local control. [119]


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