What topical agents are available for the treatment of cutaneous T-cell lymphoma (CTCL)?

Updated: Aug 15, 2018
  • Author: Lauren C Pinter-Brown, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Retinoids are vitamin A analogues involved in the modulation of cell growth, division, reproduction, and differentiation. [100] Their biologic effects result from alterations in gene expressions that are mediated through 2 major types of nuclear receptors, the retinoic acid receptor and the retinoic X receptor. Each receptor subtype likely controls the expression of unique and common genes. Subclass-specific retinoids are available.

Mechlorethamine topical (Valchlor) was approved in August 2013 for mycosis fungoides–type cutaneous T-cell lymphoma (MF-type CTCL). Approval was based on a trial in patients with refractory stage IA-IIA MF-type CTCL, in which 60% of patients treated with mechlorethamine had a confirmed response at 12 months, compared with 48% of those treated with a pharmacy-compounded mechlorethamine preparation. [101, 102, 103]


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