How effective is topical therapy for the treatment of cutaneous T-cell lymphoma (CTCL)?

Updated: Aug 15, 2018
  • Author: Lauren C Pinter-Brown, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

A majority of patients in the patch stage will have a response, usually to class I (highest potency) steroids; steroids lyse T lymphocytes and block cytokine secretion. Most cases of patch- or plaque-stage disease will respond to PUVA (76-90% complete responses); psoralens inhibit DNA synthesis in tissues exposed to psoralen and UV-A. In addition, most cases of patch- or plaque-stage disease will respond to topical chemotherapy agents, which inhibit cell growth and proliferation (complete response rate, 60%).


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