What is the role of combination chemotherapy in the treatment of cutaneous T-cell lymphoma (CTCL)?

Updated: Aug 15, 2018
  • Author: Lauren C Pinter-Brown, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Combination chemotherapy is generally not used in mycosis fungoides, because the infectious complications of this treatment, as well as the short response duration, outweigh the modest response rates (compared with those of other non-Hodgkin lymphomas) seen in this disease. Increased survival is not demonstrated with the use of combination chemotherapy relative to sequential topical agents.

However, multiagent chemotherapy is used with unequivocal lymph node or systemic involvement or in cases with widespread tumor-stage mycosis fungoides that is refractory to skin-targeted therapies and is not early patch/plaque-stage disease.

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