How is localized mycosis fungoides cutaneous T-cell lymphoma (CTCL) treated?

Updated: Aug 15, 2018
  • Author: Lauren C Pinter-Brown, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Localized mycosis fungoides may benefit from a number of therapeutic modalities, including radiotherapy, intralesional steroids, or surgical excision. One option is to excise a patch or plaque with a 0.5-cm margin and then control subsequent disease using one of the following treatment modalities [96] :

  • Irradiation
  • Photochemotherapy using ultraviolet A (UV-A) light treatment enhanced with psoralen (PUVA)
  • Photodynamic therapy
  • Carbon dioxide laser surgery

Localized radiation or a surgical approach to localized mycosis fungoides can be used. The advantage of using surgery first is that a full dose of radiation can be delivered in the same location at a later time, thus preserving options for future therapy.

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