What are the histologic findings of primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoma?

Updated: Aug 15, 2018
  • Author: Lauren C Pinter-Brown, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Histologically, this disorder shows dense, diffuse, or nodular infiltrates within the dermis that have a tendency to infiltrate the subcutis. Epidermotropism is often present focally. A predominance of small/medium-sized pleomorphic T cells may be seen, with a smaller proportion of large pleomorphic cells present. [94]

Primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoma is a CD3+, CD4+, CD8-, CD30- phenotypic lymphoma. Cytotoxic proteins are generally not expressed, and sometimes there is a loss of pan–T-cell markers. [53] The TCR genes are clonally rearranged. [70]


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