What are the histologic findings of Sézary syndrome in cutaneous T-cell lymphoma (CTCL)?

Updated: Aug 15, 2018
  • Author: Lauren C Pinter-Brown, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

The histology of Sézary syndrome may be nonspecific, but it is often similar to mycosis fungoides, although the cellular infiltrates in Sézary syndrome are more often monotonous, [88, 89] and epidermotropism may sometimes be absent. Involved lymph nodes have a dense, monotonous infiltrate of Sézary cells with effacement of the normal lymph node architecture, whereas bone marrow infiltrates, when present, are often sparse and mainly interstitial. (See the image below.) [90]

Electron micrograph of a Sézary cell. Electron micrograph of a Sézary cell.

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