What are the histologic findings of folliculotropic mycosis fungoides in cutaneous T-cell lymphoma (CTCL)?

Updated: Aug 15, 2018
  • Author: Lauren C Pinter-Brown, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Folliculotropic mycosis fungoides shows a primarily perivascular and periadnexal localization of the dermal infiltrate, with variable involvement of the follicular epithelium by small, medium, or sometimes large hyperchromatic cells with cerebriform nuclei and sparing of the epidermis (folliculotropism instead of epidermotropism). [30]

Most patients have mucinous degeneration of the follicular epithelium (follicular mucinosis)—which is best demonstrated with Alcian blue staining—and an admixture of eosinophils and sometimes plasma cells. Prominent infiltration of both follicular epithelium and eccrine sweat glands is often observed. Similar cases with prominent infiltration of eccrine sweat glands, often seen with alopecia, have been called syringotropic mycosis fungoides. [86] Basaloid folliculolymphoid hyperplasia is a distinctive finding in follicular mycosis fungoides. [87]


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