What are the biopsy findings in cutaneous T-cell lymphoma (CTCL)?

Updated: Apr 20, 2020
  • Author: Lauren C Pinter-Brown, MD; Chief Editor: Emmanuel C Besa, MD  more...
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In the study, the investigators assessed a series of 11 FNA biopsy specimens from 10 patients with mycosis fungoides or Sézary syndrome and performed flow cytometric immunophenotyping and TCR-gamma PCR assay on the FNA biopsy material. These were correlated with cytologic findings. [84]

Seven of 10 patients in the study demonstrated "lymph node involvement by cutaneous T-cell lymphoma, with 3 cases exhibiting large-cell transformation and 4 cases exhibiting a small-cell pattern."

Another 6 patients in the study were identified, using flow cytometric immunophenotyping, as having an abnormal T-cell population. In 2 cases—one in which insufficient events were present for evaluation by flow cytometry and one in which flow cytometry was not diagnostic of T-cell lymphoma—TCR-gamma PCR assay demonstrated a clonal T-cell rearrangement. Immunohistochemistry on cell block material revealed classic Hodgkin lymphoma in 2 cases.

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