What is the role of genetic testing in the workup of mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

Updated: Aug 15, 2018
  • Author: Lauren C Pinter-Brown, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Many structural and numerical chromosomal abnormalities have been described in the advanced stages of mycosis fungoides, but recurrent, mycosis fungoides–specific chromosomal translocations have not been identified. Chromosomal loss at 10q and abnormalities in P15, P16, and TP53 tumor suppressor genes are often evident with mycosis fungoides.

The neoplastic T cells in pagetoid reticulosis may have either a CD3+, CD4+, CD8- phenotype or a CD3+, CD4-, CD8+ phenotype, with CD30 often being expressed. [78]


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