What is the role of genetic testing in the workup of cutaneous T-cell lymphoma (CTCL)?

Updated: Aug 15, 2018
  • Author: Lauren C Pinter-Brown, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Neoplastic mycosis fungoides cells have a mature CD3+, CD4+, CD45RO+, CD8- memory T-cell phenotype. Rarely, otherwise-classic mycosis fungoides may have a CD4-, CD8+ mature T-cell phenotype. [76] An aberrant phenotype, such as a loss of pan–T cell antigens (eg, CD2, CD3, CD5), is not unusual.

An identical phenotype is seen in granulomatous slack skin syndrome and Sézary syndrome. Clonal T-cell receptor gene rearrangements are detected in most mycosis fungoides cases. [77]


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