Which lab tests are indicated in the workup of mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

Updated: Aug 15, 2018
  • Author: Lauren C Pinter-Brown, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Perform the following tests in the diagnostic workup of mycosis fungoides:

  • Conduct a complete blood count (CBC) with differential, and review the buffy coat smear for Sézary cells

  • Look for liver-associated enzyme abnormalities; abnormal transaminase values may indicate hepatic involvement

  • Obtain uric acid and lactate dehydrogenase (LDH) levels, since uric acid and LDH are markers of bulky and/or biologically aggressive disease

  • Conduct a flow cytometric study of the blood (include available T-cell–related antibodies) to detect a circulating malignant clone and to assess immunocompetence by quantifying the level of CD8-expressing lymphocytes

  • Consider human immunodeficiency virus (HIV) and HTLV-I testing


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