What are the approach considerations in the workup of mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

Updated: Aug 15, 2018
  • Author: Lauren C Pinter-Brown, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

For mycosis fungoides, clinical features, the history of the disease, and histomorphologic and cytomorphologic findings yield clues that lead to a diagnosis in most cases. However, demonstration of a dominant T-cell clone in skin biopsy specimens by a molecular assay (ie, Southern blot, polymerase chain reaction [PCR]) constitutes an additional diagnostic criterion to distinguish cutaneous T-cell lymphoma from inflammatory dermatoses.


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