What is the clinical history of folliculotropic mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

Updated: Apr 20, 2020
  • Author: Lauren C Pinter-Brown, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Folliculotropic mycosis fungoides is commonly first evident clinically with alopecia, follicular cysts, or comedolike lesions and is usually associated with follicular mucinosis and strong epidermotropism. [66] It is most commonly seen on the head and neck, often showing infiltrated plaques together with acneiform comedolike papules, epidermal cysts, and keratosis pilaris–like papules. [67] When mucin is present, the disease is also called alopecia mucinosa.

However, the benign form of alopecia mucinosa, which is not associated with mycosis fungoides, must be distinguished from mycosis fungoides associated with mucinosis. The most relevant feature, with and without associated follicular mucinosis, is the deep follicular and perifollicular localization of the neoplastic infiltrates, which makes them less accessible to skin-targeted therapies.

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