What is the clinical history of pagetoid reticulosis cutaneous T-cell lymphoma (CTCL)?

Updated: Aug 15, 2018
  • Author: Lauren C Pinter-Brown, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Pagetoid reticulosis arises preferentially on acral skin. The histologic hallmark of the disease is the pagetoid spread of haloed lymphoid cells in the epidermis.

Patients with localized pagetoid reticulosis are usually first seen with a solitary psoriasiform or hyperkeratotic patch or plaque, which is usually localized on the extremities; it is slowly progressive. In contrast to classic mycosis fungoides, extracutaneous dissemination and disease-related deaths rarely occur. (Ketron-Goodman disease, which is multilesional, has a clinical course similar to that of mycosis fungoides. Some cases may actually represent primary cutaneous epidermotropic CD8+ (cytotoxic) T-cell lymphoma.)


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