What is the clinical history large cell transformation of mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

Updated: Aug 15, 2018
  • Author: Lauren C Pinter-Brown, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Mycosis fungoides in any stage may suddenly become much more aggressive, progressing rapidly to more advanced stages (see the images below). This is associated with the histologic appearance of large, atypical cells; often, these are CD30+, and the process is termed large cell transformation. It may be evident as a new, solitary nodule within a classic mycosis fungoides patch or plaque, as abrupt onset of multiple scattered papules and/or nodules without spontaneous resolution, or within new or enlarging tumors. [61]

Middle-aged woman with mycosis fungoides showing u Middle-aged woman with mycosis fungoides showing ulceration and marked depigmentation of advanced disease.
Middle-aged woman with mycosis fungoides showing u Middle-aged woman with mycosis fungoides showing ulceration and marked depigmentation of advanced disease.

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