What is the prognosis of the provisional entities of cutaneous T-cell lymphoma (CTCL)?

Updated: Aug 15, 2018
  • Author: Lauren C Pinter-Brown, MD; Chief Editor: Emmanuel C Besa, MD  more...
  • Print
Answer

Primary cutaneous CD4+ small/medium pleomorphic T-cell lymphoma is associated with a relatively favorable prognosis, with an estimated 5-year survival rate of approximately 60-80%. [53] Patients first seen with solitary or localized skin lesions tend to have an excellent prognosis.

Primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma often has an aggressive clinical course, and patients have a median survival period of 32 months. [38]

Cutaneous gamma/delta-positive T-cell lymphoma patients tend to have aggressive disease resistant to multiagent chemotherapy and/or radiation, with a median survival in 1 study of only 15 months. [57] A trend toward decreased survival was noted for patients with subcutaneous fat involvement, in comparison with patients who had epidermal or dermal disease only.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!