What is the prognosis of the provisional entities of cutaneous T-cell lymphoma (CTCL)?

Updated: Apr 20, 2020
  • Author: Lauren C Pinter-Brown, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Primary cutaneous CD4+ small/medium pleomorphic T-cell lymphoma is associated with a relatively favorable prognosis, with an estimated 5-year survival rate of approximately 60-80%. [57] Patients first seen with solitary or localized skin lesions tend to have an excellent prognosis.

Primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma often has an aggressive clinical course, and patients have a median survival period of 32 months. [40]

Cutaneous gamma/delta-positive T-cell lymphoma patients tend to have aggressive disease resistant to multiagent chemotherapy and/or radiation, with a median survival in 1 study of only 15 months. [61] A trend toward decreased survival was noted for patients with subcutaneous fat involvement, in comparison with patients who had epidermal or dermal disease only.

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