Which age groups are most commonly affected by cutaneous T-cell lymphoma (CTCL)?

Updated: Aug 15, 2018
  • Author: Lauren C Pinter-Brown, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Most patients with cutaneous T-cell lymphoma are middle-aged or elderly. Sézary syndrome, for example, occurs almost exclusively in adults. Many patients have had a poorly defined form of dermatitis for many years prior to the onset of the disease. In a significant proportion of cases, the onset of the disease, or of a dermatitic precursor of the disease, occurs in childhood.

However, cutaneous T-cell lymphoma is exceedingly rare in children younger than 10 years, and in such cases it does not show a male predominance; one series even reported a strong female predilection. Similar to adult patients, most children present in stage IA or IB and have a good to excellent prognosis with treatment, although cases progressing to plaque, tumor-stage disease, and death have been reported.

Some patients with limited mycosis fungoides are described as having Woringer-Kolopp disease (pagetoid reticulosis). These patients are usually middle-aged, with an age distribution in one series ranging from 13-68 years and with a mean age of 55 years.


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