What is the prevalence of cutaneous T-cell lymphoma (CTCL)?

Updated: Apr 20, 2020
  • Author: Lauren C Pinter-Brown, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Cutaneous T-cell lymphoma has a worldwide distribution; some studies have identified a higher prevalence of the disease in industrial populations (eg, among workers who use machine cutting oils). The incidence of cutaneous T-cell lymphoma in the United States was reported to be 6.4 persons per million population annually (for the overall, age-adjusted incidence) between 1973 and 2002, with the disease’s incidence increasing over that time period. [45]

Adult T-cell lymphoma/leukemia is endemic in areas with a high prevalence of HTLV-1 infection, such as southwest Japan, the Caribbean islands, South America, and parts of central Africa. This disease occurs in 1-5% of seropositive individuals after more than 2 decades of viral persistence. [46]

Nasal-type NK/T-cell lymphoma, which is associated with Epstein-Barr virus (EBV) infection, is more common in Asia, Central America, and South America.

A study in Kuwait found that the annual incidence rate of mycosis fungoides there was 0.43 case per 100,000 persons. [47]

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