What environmental factors play a role in the etiology of cutaneous T-cell lymphoma (CTCL)?

Updated: Aug 15, 2018
  • Author: Lauren C Pinter-Brown, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Chemical, physical, and microbial irritants have been discussed as causes for cutaneous T-cell lymphoma or mycosis fungoides, but evidence related to an etiology is not convincing. [30] They may play the role of a persistent antigen, which, in a stepwise process, leads to an accumulation of mutations in oncogenes, suppressor genes, and signal-transducing genes. [32] Various theories also implicate occupational or environmental exposures (eg, Agent Orange).


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