How is mycosis fungoides cutaneous T-cell lymphoma (CTCL) treated?

Updated: Apr 20, 2020
  • Author: Lauren C Pinter-Brown, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Symptomatic treatments, emollients, or antipruritics, plus specific topical and systemic treatment, are used to manage mycosis fungoides. Generally, topical therapies are indicated for stage I patients, and systemic therapies or combinations of topical and systemic therapies are indicated for patients with stage IIB disease or greater or for patients with refractory stage I disease. [8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18]

Localized mycosis fungoides therapy may include radiotherapy, intralesional steroids, or surgical excision, as well as the following:

  • Extracorporeal photopheresis, alone or in combination with other treatment modalities (eg, IFN-α) [19] : Sézary syndrome, erythrodermic mycosis fungoides

  • Unrelated cord blood transplantation [20] : Mycosis fungoides

  • Allogeneic stem cell transplantation: Treatment-refractory mycosis fungoides [8]

  • Multiagent chemotherapy: Unequivocal lymph node or systemic involvement, or widespread tumor-stage mycosis fungoides that is refractory to skin-targeted therapies and is not early patch or plaque-stage disease

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