What are the diagnostic criteria for Sézary syndrome cutaneous T-cell lymphoma (CTCL)?

Updated: Aug 15, 2018
  • Author: Lauren C Pinter-Brown, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

For a diagnosis of Sézary syndrome, one or more of the following criteria should be met [3] :

  • Absolute Sézary cell count of at least 1000 cells/µL

  • Immunophenotypic abnormalities (expanded CD4+ T-cell population resulting in CD4/CD8 ratio of >10; loss of any or all of T-cell antigens CD2, CD3, CD4, and CD5; or loss of both CD4 and CD5)

  • T-cell clone in the peripheral blood shown by molecular or cytogenetic methods: Flow cytometry may be useful for differential diagnosis of precursor and peripheral T-cell and NK-cell lymphomas [4]


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