Which medications in the drug class Corticosteroids are used in the treatment of Brucellosis?

Updated: Apr 22, 2021
  • Author: Nicholas John Bennett, MBBCh, PhD, FAAP, MA(Cantab); Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Corticosteroids

In patients with brucellosis, corticosteroids are indicated to reduce inflammation and improve neurologic outcome. The addition of anti-inflammatory therapy with methylprednisolone or another corticosteroid may be beneficial in patients with severe or diffuse CNS involvement, cranial neuropathies, optic neuritis, or arachnoiditis.

Dexamethasone (Baycadron)

The use of corticosteroids is reserved for symptomatic Brucella meningitis. Although these agents are generally recommended, scientific evidence supporting their use is lacking. No consensus exists on optimal dosing, frequency, or duration of therapy.

Methylprednisolone (A-Methapred, Medrol, Depo-Medrol, Solu-Medrol)

Methylprednisolone decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reversing increased capillary permeability.


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