Which drugs display activity with low relapse rates against Brucella species?

Updated: Apr 22, 2021
  • Author: Nicholas John Bennett, MBBCh, PhD, FAAP, MA(Cantab); Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Although many antibiotics display in vitro activity against Brucella species, clinical response has been demonstrated with only a few of them. Drugs that display clinical activity with low relapse rates include doxycycline, gentamicin, streptomycin, rifampin, and trimethoprim-sulfamethoxazole (TMP-SMZ). Other agents with potential roles are chloramphenicol, imipenem-cilastatin, and various fluoroquinolones. When relapse occurs, the development of antibiotic resistance does not appear to be the underlying cause.

Corticosteroids are indicated to reduce inflammation and improve neurologic outcome in patients with neurobrucellosis.


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