What are the treatment options for neurobrucellosis?

Updated: Apr 22, 2021
  • Author: Nicholas John Bennett, MBBCh, PhD, FAAP, MA(Cantab); Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Patients with nervous system infections typically require combination therapy. Doxycycline is generally preferred to tetracyclines or aminoglycosides because the latter are less likely to cross the blood-brain barrier in adequate quantities. Many authorities prefer a 3-drug (doxycycline-streptomycin-rifampin or doxycycline−TMP-SMZ−rifampin) regimen to a 2-drug regimen. A brief course of adjunctive corticosteroid therapy has been used to control the inflammatory process, but studies are limited.


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