What is the efficacy of combined doxycycline and streptomycin for the treatment of brucellosis?

Updated: Apr 22, 2021
  • Author: Nicholas John Bennett, MBBCh, PhD, FAAP, MA(Cantab); Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

A 2012 Cochrane review found that a regimen consisting of doxycycline for 6 weeks plus streptomycin for 2-3 weeks was more effective than one consisting of doxycycline plus rifampicin for 6 weeks. [59] The investigators also found that a regimen consisting of a fluoroquinolone plus rifampicin for 6 weeks was as effective overall as doxycycline plus rifampin (though the evidence for this conclusion was of low quality) and was slightly better tolerated.


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