What is the role of doxycycline in the treatment of brucellosis?

Updated: Apr 22, 2021
  • Author: Nicholas John Bennett, MBBCh, PhD, FAAP, MA(Cantab); Chief Editor: Michael Stuart Bronze, MD  more...
  • Print
Answer

For simple infections, doxycycline (100 mg PO twice daily for 6 weeks) may be the most appropriate monotherapy; however, relapse rates with such monotherapy approach 40% and as a result, rifampin (600-900 mg/day) is usually added. Fluoroquinolones (eg, ciprofloxacin) have been used as monotherapy as well but also carry a high relapse rate; adding these agents to doxycycline offers no specific advantages over other combination regimens but may be preferred in areas where resistance to rifampin is high.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!