What phenomenon my case a false-negative finding for brucellosis and how is it prevented?

Updated: Apr 22, 2021
  • Author: Nicholas John Bennett, MBBCh, PhD, FAAP, MA(Cantab); Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Prozone phenomenon may occur secondary to hyperantigenemia, possibly leading to false-negative results. Accordingly, routine dilution of sera (typically beyond 1:320) is necessary to avoid this problem.


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