What is the role of inhaled magnesium for the treatment of status asthmaticus?

Updated: Jun 17, 2020
  • Author: Constantine K Saadeh, MD; Chief Editor: John J Oppenheimer, MD  more...
  • Print

Inhaled magnesium sulfate has generated some interest with regard to the treatment of status asthmaticus, when combined with beta-agonist use. [39]

In a retrospective study by Vaiyani and Irazuzla, [40] magnesium sulfate infusion for status asthmaticus in children was evaluated. Two groups of patients were identified. Nineteen of the first group received high-dose prolonged magnesium infusions consisting of 75 mcg/kg if the weight was less than 30 kg. If the weight was more than 30 kg, the dose was 50 mg/kg. In both situations, the infusion of magnesium sulfate was continuous over 4 hours given at 40 mg/kg/h. In the second group, no loading dose was given. The dose was 50 mg/kg/h over 5 hours. There was no difference in the magnesium concentration in the serum in both of these groups, and the amount of bronchodilation was similar. Based these and other data, magnesium sulfate remains an important regimen in the treatment of status asthmaticus, with excellent tolerability. [41]

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!