What is the efficacy of magnesium sulfate for the treatment of status asthmaticus?

Updated: Jun 17, 2020
  • Author: Constantine K Saadeh, MD; Chief Editor: John J Oppenheimer, MD  more...
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Answer

No data regarding duration of effect or efficacy with repeated doses are available, and no guidelines describe the monitoring of serum magnesium levels if more than an initial magnesium dose is administered. In one small study of four children who received 40-50 mg/kg of magnesium sulfate, serum magnesium levels were all less than 4 mg/dL, whereas electrocardiographic changes are generally not seen until levels exceed 4-7 mg/dL. Adverse effects may include facial warmth, flushing, tingling, nausea, and hypotension.

This therapy can be tried, especially in pregnant women, as an adjunct to beta2 bronchodilator therapy. However, more studies have not confirmed the effectiveness of this treatment, [37, 38] and its use is still controversial.


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