What is the role of aminophylline in the treatment of status asthmaticus?

Updated: Jun 17, 2020
  • Author: Constantine K Saadeh, MD; Chief Editor: John J Oppenheimer, MD  more...
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Conflicting reports on the efficacy of aminophylline therapy have made it controversial. Starting intravenous aminophylline may be reasonable in patients who do not respond to medical treatment with bronchodilators, oxygen, corticosteroids, and intravenous fluids within 24 hours. [35]

Data suggest that aminophylline may have an anti-inflammatory effect in addition to its bronchodilator properties. The loading dose is usually 5-6 mg/kg, followed by a continuous infusion of 0.5-0.9 mg/kg/h.

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