What is the role do glucocorticosteroids in the treatment of status asthmaticus?

Updated: Jun 17, 2020
  • Author: Constantine K Saadeh, MD; Chief Editor: John J Oppenheimer, MD  more...
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Answer

Glucocorticosteroids are the most important treatment for status asthmaticus. [30] These agents can decrease mucus production, improve oxygenation, reduce beta-agonist or theophylline requirements, and activate properties that may prevent late bronchoconstrictive responses to allergies and provocation.

In addition, corticosteroids can decrease bronchial hypersensitivity, reduce the recovery of eosinophils and mast cells in bronchioalveolar lavage fluid, decrease the number of activated lymphocytes, and help to regenerate the bronchial epithelial cells.


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