What is the role of leukotriene modifiers in the treatment of status asthmaticus?

Updated: Jun 17, 2020
  • Author: Constantine K Saadeh, MD; Chief Editor: John J Oppenheimer, MD  more...
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Leukotriene modifiers are useful for treating chronic asthma but not acute asthma. This treatment may be beneficial if used via a nebulizer, but it remains experimental. Most studies have examined intravenous use. [19, 20]  Montelukast can be used as an add-on treatment for asthma in general. It is mostly used for improving the quality of life as an add-on therapy to inhaled corticosteroids and not necessarily just for status asthmaticus. There has been one study that showed minimal to no effect of using montelukast in the emergency department setting for patients with status asthmaticus. [21, 22] In general, it did not show any significant benefit. It is not used specifically for status asthmaticus prevention.


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