Which medications in the drug class HMG-CoA Reductase Inhibitors are used in the treatment of Posterior Cerebral Artery Stroke?

Updated: Jul 30, 2018
  • Author: Erek K Helseth, MD; Chief Editor: Helmi L Lutsep, MD  more...
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Answer

HMG-CoA Reductase Inhibitors

In patients with elevated cholesterol, sustained reduction in cholesterol levels may also reduce the chances of stroke. These agents lower LDL-C levels by reducing the production of mevalonic acid from HMG-CoA and by stimulating LDL catabolism. They also lower triglyceride levels and raise serum HDL-C levels, and they have a low incidence of adverse effects, the most common being hepatotoxicity and myopathy.

Lovastatin (Altoprev, Mevacor)

Competitively inhibits HMG-CoA, which catalyzes rate-limiting step in cholesterol synthesis. Adjunct to dietary therapy in reducing serum cholesterol. Before initiating therapy, place patients on cholesterol-lowering diet for 3-6 mo, and continue diet indefinitely.

Simvastatin (Zocor)

Competitively inhibits HMG-CoA, which catalyzes rate-limiting step in cholesterol synthesis. In addition, agents in this class possess pleitropic properties including improved endothelial function and reduced inflammation at the site of the coronary plaque. Before initiating therapy, place patients on cholesterol-lowering diet for 3-6 mo, and continue diet indefinitely.

Pravastatin (Pravachol)

Competitively inhibits HMG-CoA, which catalyzes rate-limiting step in cholesterol synthesis. Agents in this class also inhibit platelet aggregation and have anticoagulant effects. Before initiating therapy, place patients on cholesterol-lowering diet for 3-6 mo, and continue diet indefinitely.

Atorvastatin (Lipitor)

Competitively inhibits HMG-CoA, which catalyzes rate-limiting step in cholesterol synthesis. Agents in this class also decrease levels of high-sensitivity C-reactive protein, which is a protein associated with inflammatory responses. Before initiating therapy, place patients on cholesterol-lowering diet for 3-6 mo, and continue diet indefinitely.


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