What is the treatment for amebic colitis?

Updated: Jul 19, 2019
  • Author: Vinod K Dhawan, MD, FACP, FRCPC, FIDSA; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Nitroimidazole therapy leads to clinical response in approximately 90% of patients with mild-to-moderate amebic colitis. Because intraluminal parasites are not affected by nitroimidazoles, nitroimidazole therapy for amebic colitis should be followed by treatment with a luminal agent (eg, paromomycin or diloxanide furoate) to prevent a relapse. [4] A 2019 Cochrane Database Review reported that tinidazole may be more effective than metronidazole and is associated with fewer adverse events. [71] Combination drug therapy may be more effective for reducing parasitological failure compared with metronidazole alone. [71]


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