What is the role of loop-mediated isothermal amplification (LAMP) assay in the diagnosis of amebiasis?

Updated: Jul 19, 2019
  • Author: Vinod K Dhawan, MD, FACP, FRCPC, FIDSA; Chief Editor: Michael Stuart Bronze, MD  more...
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The loop-mediated isothermal amplification (LAMP) assay has been applied to the detection of E histolytica in cases of hepatic amebiasis. A study that compared this test with PCR testing in 50 patients with clinical suspicion of amebic liver abscess found that LAMP assay detected 5 additional abscesses that were missed by PCR assay. [63] The rapidity, operational simplicity, high specificity and sensitivity, and high yield of LAMP assay suggest that it may prove to be a better diagnostic tool than PCR assay for diagnosis of hepatic amebiasis.

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