How are serum antibodies detected in amebiasis?

Updated: Jul 19, 2019
  • Author: Vinod K Dhawan, MD, FACP, FRCPC, FIDSA; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

ELISA, the assay most commonly used worldwide, measures the presence of serum antilectin antibodies (immunoglobulin G [IgG]). The galactose lectin antigen is present in the serum of 75% of subjects with amebic liver abscess and may be particularly useful in patients presenting acutely, before an IgG antiamebic antibody response occurs. The sensitivity of ELISA for detection of antibodies to E histolytica in patients with amebic liver abscess is 97.9%, and its specificity is 94.8%. False-negative results can occur within the first 7-10 days after infection.


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