What is the role of EMG in the workup of early symptomatic HIV infection?

Updated: Jan 02, 2019
  • Author: Robert J Carpenter, DO, AAHIVS, FACP; Chief Editor: John Bartlett, MD  more...
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Answer

In patients with HIV myopathy, EMG is a sensitive diagnostic test. The most common finding on muscle biopsy is scattered myofiber degeneration with occasional inflammatory infiltrates. Other pathological findings include nemaline rod bodies, cytoplasmic bodies, and mitochondrial abnormalities. Serial creatine kinase levels are useful for monitoring the course of the disorder.

EMG is also useful for evaluating mononeuritis multiplex. Results generally reveal multifocal axonal neuropathy. Biopsy of nerve tissue reveals inflammation and vasculitis. In some cases, CMV inclusions have been found.

In patients with elevated transaminases, acute viral hepatitis A, B, and C should be excluded with appropriate serologic testing.


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