Which histologic findings are characteristic of adenovirus-related pneumonia?

Updated: Apr 15, 2021
  • Author: Sandra G Gompf, MD, FACP, FIDSA; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Obliterative bronchiolitis is seen; viral intranuclear and intracytoplasmic inclusions with positive immunohistochemical staining specific for adenovirus are noted. The intranuclear inclusions during late infection are surrounded by a clear halo, which may obstruct visualization of the nuclear membrane, resulting in a smudged appearance. These "smudged" cells are classically seen in adenovirus infection.


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