What is the role of serology in the diagnosis of adenovirus infections?

Updated: Apr 15, 2021
  • Author: Sandra G Gompf, MD, FACP, FIDSA; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Seroreactivity to adenovirus is common. As a result, serology is available through commercial laboratories, but is less useful in the acute clinical setting. By age 4 years, approximately half of all children have positive adenovirus titers. If a serologic diagnosis is pursued, serum should be obtained as early as possible in the clinical course, followed by a second titer 2-4 weeks later. A 4-fold rise in acute titers to convalescent titers is diagnostic.


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