Which medications in the drug class Antiretroviral agent, non-nucleoside reverse-transcriptase inhibitor are used in the treatment of HIV Infection and AIDS?

Updated: Oct 08, 2019
  • Author: Nicholas John Bennett, MBBCh, PhD, MA(Cantab), FAAP; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Antiretroviral agent, non-nucleoside reverse-transcriptase inhibitor

NNRTIs inhibit viral replication.

Delavirdine (Rescriptor)

An NNRTI of HIV-1, delavirdine directly binds to reverse transcriptase and inhibits RNA- and DNA-dependent DNA polymerase.

Efavirenz (Sustiva)

Efavirenz is an NNRTI with activity against HIV-1. This agent binds to reverse transcriptase and blocks RNA-dependent and DNA-dependent DNA polymerase activities, including HIV-1 replication. Efavirenz does not require intracellular phosphorylation for antiviral activity.

Etravirine (Intelence)

Etravirine is an NNRTI of HIV-1 that binds directly to reverse transcriptase, causing catalytic site disruption. This action blocks RNA- and DNA-dependent DNA polymerase activities. Etravirine does not inhibit human DNA polymerases alpha, beta, or gamma.

This agent is indicated for use in combination with other antiretroviral agents for treatment-experienced HIV-infected adults who have viral replication and HIV-1 strains resistant to NNRTIs and other antiretroviral agents. If virologic failure was experienced with other NNRTIs, do not use etravirine in combination with NRTIs only.

Nevirapine (Viramune)

Nevirapine is an NNRTI that limits virus replication by a mechanism different from the nucleosidase inhibitors such as zidovudine and lamivudine.

Rilpivirine (Edurant)

Rilpivirine is a NNRTI that inhibits HIV-1 replication by noncompetitive inhibition of HIV-1 reverse transcriptase. It does not inhibit the human cellular DNA polymerases alpha, beta, and gamma.

Doravirine (Pifeltro)

Indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults (1) who have not undergone antiretroviral therapy (ART) or (2) as a replacement for the current antiretroviral regimen in patients who are who are virologically suppressed (HIV-1 RNA


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